I am a Pharmacist registered with the Pharmacy and Poisons Board of Kenya and a graduate of the University of Nairobi with a bachelor’s degree in Pharmacy. I have just completed my masters in Clinical Pharmacy at the University of Nairobi awaiting to graduate. I have outstanding interpersonal skills, I am reliable, trustworthy, numerate and meticulous. I am passionate about causing a positive change in people’s lives; this I do daily by ensuring that the people I encounter and interact with get the best medication outcomes for their illnesses. Currently I work as hospital Pharmacist at Kakamega County General Teaching and Referral Hospital.
Project Summary
Rational Use of Antibiotics Among Patients Admitted to Critical Care Units at Kenyatta National Hospital and Its Impact on Clinical Outcomes.
Background: Irrational use of antibiotics is associated with antimicrobial resistance and high mortality rate in the critical care units. In Kenya, there is scarce data on rational use of antibiotics within critical care units and its impact on patient clinical outcomes.
Objectives: To evaluate rational use of antibiotics among patients admitted to various Critical Care Units at Kenyatta National Hospital and its impact on clinical outcomes.
Methods: Retrospective, cross-sectional record review of admissions to the KNH CCUs conducted over two years. Socio-demographic and clinical characteristics of patients were captured in a predesigned tool. Associations between clinical characteristics and mortality were calculated at p<0.05.
Results: Cephalosporins (49.6%), 5-nitroimidazoles (18.2%) and penicillins (14.2%) were the most frequently prescribed classes of antibiotics. The prevalence of irrational use of antibiotics was high at 81.5%. Mortality at critical care units was 11.1%, with the odds of death being at least five times among intubated patients compared to those who were not (AOR 5.5, 95% CI=1.1-28.1, p=0.042).
Conclusion: The prevalence of rational antibiotic use was 18.5%. The high proportion of irrational use was contributed by incorrect choice and incorrect duration of antibiotic use.
Supervisors
Dr. David G. Nyamu,
Dr. Rosaline N. Kinuthia,
Dr. Peter Njogu
Links
https://scholar.google.com/citations?view_op=new_articles&hl=en&imq=MURILA+BABRA+LIGOGO&authuser=6#
